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The NF-B signaling pathway, activated in 80% of RA synovium, drives cytokine production, while the Janus kinase (JAK)/signal transducers and activator of transcription (STAT) pathway mediates IL-6 signaling, contributing to chronic inflammation (11)

This disruption of DNA replication and repair and HSP protein refolding can trigger mitotic arrest and even apoptosis when injury is severe

PMID:30720723;PMCID:PMC6406831

are small and yellow, occurring either solitarily or in small clusters at the leaf axils

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